You can deliver your items to anywhere. However, you will have to check the shipping rates to various countries with your delivery service. This will also enable you to set the price of your items accordingly. Some countries may impose restrictions on certain items so please check with your delivery service first before specifying the countries you are able to ship your items to.
Assuming shipping costs and handling fees vary across the countries you ship to, you may wish to create a new product for every country, with the various fees included within the total prices.
eg. Product 1 - 'XYZ Framed Art to USA'
Product 2 - 'XYZ Framed Art to Canada'